UNDERSTANDING & COMBATING ANTIBIOTIC RESISTANCE
Antibiotic resistance (AMR) poses a significant challenge to global health, agriculture, and environmental sustainability. At our lab, we are at the forefront of addressing this critical issue through a comprehensive research approach that integrates molecular biology and epidemiology with the ONE HEALTH framework. This interdisciplinary method allows us to explore how antibiotic resistance genes (ARGs) are transmitted and develop effective strategies to mitigate their spread.
Mapping the Prevalence of AMR locally
We have meticulously collected over 700 samples from various sources around Harare, including food animals (poultry, porcine, bovine, ovine, and sheep), as well as environmental samples (water and waste). This extensive data set helps us to build a detailed picture of the prevalence of antibiotic resistance in our region.
Understanding Transmission Dynamics
By examining these samples, we investigate the transmission pathways of antibiotic resistance genes. This includes analyzing how resistance spreads among different species and environments, which is crucial for developing targeted interventions.
Deciphering Molecular Mechanisms
Our lab employs advanced molecular and cell biological techniques to study extended spectrum beta-lactamases (ESBLs), a key group of enzymes contributing to antibiotic resistance. Our preliminary findings, which are soon to be published, offer valuable insights into the ESBL landscape in Harare and highlight areas for further research and intervention.
Our research not only contributes to the scientific understanding of AMR but also informs public health policies and practices. By identifying critical patterns and mechanisms of resistance, we provide evidence that supports the development of effective strategies to combat AMR at local, national, and global levels. We invite policymakers, scientific experts, and potential funders to engage with our research. Your support and collaboration are essential in advancing our efforts to combat antibiotic resistance and protect public health and the environment.