Understanding & countering Anti-microbial Drug Resistance (AMR)
Our lab tackles antibiotic resistance (AMR) using a ONE HEALTH approach, combining molecular biology and epidemiology. We have collected over 700 samples from Harare, including food animals and environmental sources, to study the prevalence and transmission of antibiotic resistance genes (ARGs). Our focus is on extended spectrum beta-lactamases (ESBLs), crucial enzymes in resistance. Preliminary results, soon to be published, reveal important insights into the ESBL landscape in Harare. Our findings aim to inform effective interventions and policy development. We invite policymakers, experts, and funders to support our vital work in combating AMR.
STI and HPV Research
Sexually transmitted infections (STIs) including human papillomaviruses (HPVs) are prevalent in Zimbabwe and Sub-Saharan Africa, contributing to high rates of cervical cancer and other health complications. Limited access to screening, prevention and treatment exacerbates the issue, particularly among women. At the Biotech Institute, our research focus on genomic analysis and the development of targeted diagnostics to improve earlly detection and treatment of STIs and HPVs. By creating region-specific solutions, our work aims to enhance healthcare outcomes, reduce the burden of these diseases, and improve the overall quality of life for affected populations in Zimbabwe.
Cancer Genomics Platform
A cancer genomics platform using Next-Generation sequencing (NGS) and bioinformatics could transform cancer care in Zimbabwe and Sub-Saharan Africa. NGS enables the identification of unique, region-specific mutations, but challenges like limited infrastructure, funding and the under-presentation of African data in global variant databases hinder it's implementation. Developing tailored bioinformatics pipelines and African-specific variant databases is crucial. Despite these challenges the platform would enable precision medicine, improve early cancer detection, and advance pharmacogenomics, significantly reducing cancer mortality. With strategic investment and capacity building, Africa could become a leader in cancer genomics research and healthcare.
Mycotoxins
Mycotoxins are toxic substances produced by certain molds or fungi that can contaminate various agricultural products, including cereals, grains, nuts, fruits, and animal feeds. These toxins pose a significant threat to human and animal health, as they can cause acute or chronic illnesses, and are a matter of great concern for the food and feed industry. Consequently, mycotoxin testing is crucial to ensure the safety and quality of our food supply chain.
Enzyme Biotechnology
Enzymes are proteins that can be exploited to achieve a variety of biotechnological or biocatalytical applications. In our enzyme biotechnology sub-group, we employ biophysics, random mutagenesis and directed evolution to study and optimize enzymes for various purposes, in particular, increasing the nutrient-content in livestock feed and bio-degradation of plastics.
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